Description
Product Characteristics: CAP 2 antibody, CAP-2 antibody, CAP2 antibody, Cytoplasmic antiproteinase 2 antibody, OTTHUMP00000067000 antibody, OTTHUMP00000067001 antibody, Peptidase inhibitor 8 antibody, PI 8 antibody, PI-8 antibody, PI8 antibody, Protease inhibitor 8 (ovalbumin type) antibody, Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 8 antibody, Serpin B8 antibody, Serpin peptidase inhibitor clade B (ovalbumin) member 8 antibody, Serpinb8 antibody, SPB8_HUMAN antibody
Target Information: The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8\, SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]